Screening of targeted genes in extrahepatic bile ducts of mice with experimental biliary atresia

Screening of targeted genes in extrahepatic bile ducts of mice with experimental biliary atresia.

Biliary atresia (BA) is an infantile disease resulting from a severe cholangiopathy, which can obstruct extrahepatic bile ducts, disrupt bile flow and lead to end‑stage cirrhosis. The current study aimed to develop a genetic method to investigate the pathogenesis of BA. The gene expression profile of BA (GSE46967) was downloaded from the Gene Expression Omnibus database and included 18 samples ...

Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia.

The etiology and pathogenesis of bile duct obstruction in children with biliary atresia are largely unknown. We have previously reported that, despite phenotypic heterogeneity, genomic signatures of livers from patients display a proinflammatory phenotype. Here, we address the hypothesis that production of IFN-gamma is a key pathogenic mechanism of disease using a mouse model of rotavirus-induc...

Congenital Extrahepatic Biliary Atresia

Case 1. The elder of two sibs, this boy was born on May 21, 1965 to unrelated healthy parents aged 29 (mother) and 30 years (father). Birthweight was 2820 g.; delivery was by forceps. His mother had 'influenza' between the fifth and sixth months of the pregnancy which had been otherwise normal. There was no previous foetal loss. Four generations of the family, comprising, in addition to the par...

Gene expression profiling of extrahepatic ducts in children with biliary atresia.

As an inflammatory obliterative cholangiopathy of neonates, biliary atresia (BA) affects both intrahepatic and extrahepatic bile ducts. Its etiology has remained largely unknown. Gene expression profiling was conduced for extrahepatic bile duct tissues (including porta hepatis & common bile duct) to identify novel targets for further studies of BA. Among these tissues, porta hepatis was regarde...

Extrahepatic Biliary Atresia